Oligonucleotide Synthesis Market

Market Overview

The oligonucleotide synthesis market is witnessing remarkable expansion, fueled by a growth in demand for customized oligonucleotides across diverse sectors like research, diagnostics, and therapeutics. Oligonucleotides, comprising short DNA or RNA sequences, serve multi-layered roles such as gene synthesis, PCR, gene editing, and molecular diagnostics. The growing field of personalized medicine and targeted therapies, particularly in oncology and genetic disorders, emerges as a primary driver propelling market advancement. The arrival of CRISPR technology and other gene-editing tools intensifies the need for synthetic oligonucleotides. Opportunities are present in the market, driven by paces in synthetic biology and next-generation sequencing, which broaden the horizons of oligonucleotide applications. The escalating interest in mRNA-based vaccines and therapeutics, especially in response to the COVID-19 pandemic, presents another opportunity ready for substantial growth. The trend toward lab automation and miniaturization enhances synthesis processes, increasing efficiency and cost-effectiveness, thereby stimulating market expansion. Even though it has a promising path, challenges such as elevated costs and regulatory complexities loom over the market. However, persistent innovation and strategic collaborations within the industry are anticipated to propel further growth, ushering in fresh opportunities for market participants.

Oligonucleotide Synthesis Market Size

Report	Details
Market Size Value	USD 8.4 billion in 2024
Market Size Value	USD 22.9 billion by 2030
CAGR	CAGR of 15.5%
Forecast Period	2024-2032
Base Year	2023
Historic Data	2020
Segments Covered	Product Type, Application, Scale and Region
Geographics Covered	North America, Europe, Asia Pacific, and RoW

Major vendors in the global Oligonucleotide Synthesis market are Agilent Technologies, Inc., Biolegio, Biolytic Lab Performance Inc., Bio-Synthesis Inc., Cytiva, DH Life Sciences, LLC., GENERI BIOTECH, Horizon Discovery Ltd., Kaneka Eurogentec S.A, LGC Limited, Maravai LifeSciences, Thermo Fisher Scientific Inc., Twist Bioscience.,  and Others.

Increased regulatory approvals of oligonucleotide-based drug

Increased regulatory approvals of oligonucleotide-based drugs serve as a pivotal driver for driving growth within the oligonucleotide synthesis market. When regulatory bodies like the FDA and EMA sanction these drugs, it not only validates their therapeutic potential but also builds confidence in the industry regarding their safety and efficacy. This validation prompts heightened investment in research and development endeavors, as companies struggle to capitalize on the growing demand for innovative therapies. With each successive approval, healthcare providers and patients alike grow more assured of these treatments, leading to widespread adoption. The successful approval of drugs like eteplirsen and nusinersen, tailored for Duchenne muscular dystrophy and spinal muscular atrophy respectively, underscores the tangible efficacy of oligonucleotide-based therapies. Such accomplishments inspire additional pharmaceutical and biotech entities to commit resources to oligonucleotide research, sustained by the assurance of a well-defined regulatory pathway for final approval and commercialization. Thus, there emerges a pronounced surge in the demand for oligonucleotide synthesis services, essential for supporting the development of these drugs. This rising demand propels the oligonucleotide synthesis market forward, convincing companies to furnish top-tier, bespoke oligonucleotides to align with the stringent standards mandated by regulatory bodies and the healthcare community.

Market Dynamics

Drivers:

• Increased regulatory approvals of oligonucleotide-based drug
• Growing adoption of personalized medicine
• Technological advancements in oligonucleotide synthesis
• Advancements in automation and miniaturization

Opportunities:

• Research and development in gene editing technologies.
• Expansion of therapeutic applications
• Growing interest in using oligonucleotides as therapeutic agents
• Increased government and private investments in genomics research

Research and development in gene editing technologies

Research and development in gene editing technologies represent a substantial growth opportunity for the oligonucleotide synthesis market. Techniques like CRISPR/Cas9, RNA interference (RNAi), and base editing heavily depend on synthetic oligonucleotides to achieve precise genetic modifications. Acting as guides, oligonucleotides enable researchers to pinpoint and modify specific DNA sequences with exceptional accuracy in CRISPR-based editing. Similarly, in RNAi-mediated gene silencing, synthetic oligonucleotides regulate gene expression, potentially addressing diverse diseases. As gene editing methods advance and find broader applications in research, diagnostics, and therapeutics, the demand for custom-made, high-quality oligonucleotides is poised to escalate. This trend opens avenues for oligonucleotide synthesis providers to diversify their offerings to meet the unique requirements of gene editing applications. The evolving landscape of gene editing fuels the necessity for oligonucleotide variants with improved stability, and precision, and minimize off-target effects, propelling innovation within the market. The growing adoption of gene editing technologies promises substantial opportunities for the oligonucleotide synthesis market, driving progress in research and the creation of novel, targeted treatments for a spectrum of genetic disorders.

North America dominates the market for oligonucleotide synthesis.

The oligonucleotide synthesis market is mainly led by North America, particularly the United States. This dominance is fueled by the region's well-established biotechnology and pharmaceutical sectors, substantial investment in research and development, and the presence of numerous influential market players. The U.S. is in the lead in adopting cutting-edge technologies like CRISPR, personalized medicine, and therapeutic oligonucleotides, which significantly propel the market's expansion. Following closely is Europe, boasting robust research institutions and a well-developed healthcare infrastructure. Particularly, countries such as the United Kingdom and Germany contribute significantly to the market due to their increased funding in life sciences and biotechnology endeavours. The European market emphasizes the development of targeted therapies and the wider integration of oligonucleotides in diagnostic applications. The Asia-Pacific region emerges as an important contender in the oligonucleotide synthesis market, driven by escalating healthcare expenditure, expanding research facilities, and increased demand for gene-based therapies. Countries like China, Japan, and South Korea are making substantial investments in biotechnology and genomics, fueling rapid market growth. Across all regions, key trends and developments include the adoption of automated synthesis technologies, the implementation of high-throughput synthesis methods, and a growing emphasis on personalized medicine and targeted therapeutics. Collaborative efforts between industry players, academic institutions, and governmental bodies are nurturing innovation and propelling advancements in oligonucleotide-based research and applications.

The reagents segments is anticipated to hold the largest market share during the forecast period

In the global Oligonucleotide Synthesis market, the Product Type segment comprises various categories such as Oligonucleotides,  Equipment/Synthesizers, and Reagents. In the Oligonucleotide Synthesis Market, the Reagents segment is projected to maintain its dominance during the forecast period. Reagents, including activators, deprotecting agents, and oxidizing agents, play a crucial role in the synthesis of oligonucleotides, which are essential components in various applications such as genetic research, drug development, and molecular diagnostics. The increasing demand for personalized medicine, advancements in gene therapy, and the growing focus on genomic studies are driving the need for high-quality oligonucleotides. As a result, the Reagents segment is expected to witness substantial growth, fueled by the rising demand for efficient and reliable reagents to support the synthesis of these vital biomolecules.

Major Segmentations Are Distributed as follows:

• By Product Type
  • Oligonucleotides
    • DNA
      • Column-based
      • Array-based
    • RNA
      • By Technology
        • Column-based
        • Array-based
      • By Type
        • Short RNA Oligos (<65 nt)
        • Long RNA Oligos (>65 nt)
        • CRISPR (sgRNA)
  • Equipment/Synthesizer
  • Reagents
• By Service
  • BNA Oligonucleotides Synthesis Service
  • CpG Oligodeoxynucleotides Synthesis Service
  • sgRNA Library
  • Single-stranded DNA (ssDNA) Synthesis Service
  • Custom mRNA Synthesis Service
  • dsRNA Synthesis Service
  • Modified DNA Oligo Synthesis Service
• By End Use
  • Hospitals
  • Pharmaceutical & Biotechnology Companies
  • Diagnostic Laboratories
  • CROs and CMOs
  • Academic Research Institutes
• By Region
  • North America
    • US
    • Canada
  • Latin America
    • Brazil
    • Mexico
    • Argentina
    • Colombia
    • Chile
    • Peru
    • Rest of Latin America
  • Europe
    • UK
    • Germany
    • France
    • Italy
    • Spain
    • Russia
    • BENELUX
    • CIS & Russia
    • Nordics
    • Austria
    • Poland
    • Rest of Europe
  • Asia Pacific
    • China
    • Japan
    • India
    • South Korea
    • Thailand
    • Indonesia
    • Malaysia
    • Vietnam
    • Australia & New Zealand
    • Rest of Asia Pacific
  • Middle East & Africa
    • Saudi Arabia
    • UAE
    • South Africa
    • Nigeria
    • Egypt
    • Israel
    • Turkey
    • Rest of Middle East & Africa

Recent Developments

• In Jan 2023, Aurisco, a Chinese pharmaceutical company and contract development and manufacturing organization (CDMO), partnered with Cytiva, a global life sciences company, to establish its inaugural Oligo FlexFactory platform for commercial production.
• In July 2023, Analytix introduced two new tools for organic synthesis: wavePREP, designed for oligonucleotide synthesis, and a multireaction synthesis workstation.

Oligonucleotide Synthesis Market Report Gives Answers to Following Key Questions:

• What will be the Oligonucleotide Synthesis Market’s Trends & growth rate? What analysis has been done of the prices, sales, and volume of the top producers of Oligonucleotide Synthesis Market?
• What are the main forces behind the worldwide Oligonucleotide Synthesis Market? Which companies dominate the Oligonucleotide Synthesis Market?
• Which companies dominate the Oligonucleotide Synthesis Market? Which business possibilities, dangers, and tactics did they embrace in the market?
• What are the global Oligonucleotide Synthesis industry's suppliers' opportunities and dangers in Oligonucleotide Synthesis Market?
• What is the Oligonucleotide Synthesis industry's regional sales, income, and pricing analysis? In the Oligonucleotide Synthesis Market, who are the distributors, traders, and resellers?
• What are the main geographic areas for various trades that are anticipated to have astounding expansion over the Oligonucleotide Synthesis Market?
• What are the main geographical areas for various industries that are anticipated to observe an astounding expansion in Oligonucleotide Synthesis Market?
• What are the dominant revenue-generating regions for Oligonucleotide Synthesis Market, as well as regional growth trends?
• By the end of the forecast period, what will the market size and growth rate be?
• What are the main Oligonucleotide Synthesis Market trends that are influencing the market's expansion?
• Which key product categories dominate the Oligonucleotide Synthesis Market? What are the Oligonucleotide Synthesis Market’s main applications?
• In the coming years, which Oligonucleotide Synthesis Market technology will dominate the market?

Reason to purchase this Oligonucleotide Synthesis Market Report:

• Determine prospective investment areas based on a detailed trend analysis of the global Oligonucleotide Synthesis Market over the next years.
• Gain an in-depth understanding of the underlying factors driving demand for different Oligonucleotide Synthesis Market segments in the top spending countries across the world and identify the opportunities each offers.
• Strengthen your understanding of the market in terms of demand drivers, industry trends, and the latest technological developments, among others.
• Identify the major channels that are driving the global Oligonucleotide Synthesis Market, providing a clear picture of future opportunities that can be tapped, resulting in revenue expansion.
• Channelize resources by focusing on the ongoing programs that are being undertaken by the different countries within the global Oligonucleotide Synthesis Market.
• Make correct business decisions based on a thorough analysis of the total competitive landscape of the sector with detailed profiles of the top Oligonucleotide Synthesis Market providers worldwide, including information about their products, alliances, recent contract wins, and financial analysis wherever available.